Daphne (/ˈdæfniː/) is a city in Baldwin County, Alabama, United States, on the eastern shoreline of Mobile Bay. The city is located along I-10, 11 miles east of Mobile and 170 miles southwest of the state capital of Montgomery. The 2010 United States Census lists the population of the city as 21,570, making Daphne the most populous city in Baldwin County. It is a principal city of the Daphne-Fairhope-Foley metropolitan area, which includes all of Baldwin County.

The inhabited history of what is now called Daphne dates at least to the Paleo-Indian period and Native American tribes around 9000 BC. Modern-day Daphne is a thriving suburb of nearby Mobile. Daphne has adopted the nickname ″The Jubilee City″ in recognition of its status as one of the locations of the Mobile Bay jubilee. The only other place jubilees occur is in Tokyo Bay.

Daphne and the surrounding regions have been populated since from at least 9,000 BCE. European settlers eventually displaced the Native Americans. After a variety of wars and treaties the area became part of the United States in 1814. Except for a period under the flag of the Confederate States of America, Daphne and its environs have remained part of the United States until this time. From Native American, to the Spanish, French and British, the city has seen a lengthy parade of historic influences which gives Daphne its present character.